Comparative study of midazolam and fentanyl for the prevention of etomidate-induced myoclonus

Background: Etomidate is one of the popular rapidly acting inducing agents with cardio-stable profile but associated side effects such as myoclonus. Myoclonus can lead to regurgitation, prolapse vitreous in open globe or many other complications. Aims and Objectives: The objectives are follows: To compare efficacy Fentanyl midazolam for prevention induced study hemodynamic parameters fentanyl patients myoclonus after etomidate injection. Materials Methods: Eighty scheduled elective surgeries under general anesthesia were randomly allotted into two groups 40 each. Group F – 1 μg/kg M 0.03 mg/kg administered pre-treatment before induction by Etomidate. After injection Etomidate, incidence was observed along change (heart rate [HR], systolic blood pressure [SBP], diastolic [DBP], mean arterial [MAP]). Comparison between 2 done at pre-treatment, min intubation. Results: Both reduced However, more effective decreasing well severity stable HR, SBP, DBP, MAP intubation (P<0.05). In both groups, there no increased PONV. Conclusion: reduce compared midazolam.